| Experiment Id | E-MTAB-4526 | Name | RNA-seq of cold-induced transcriptome changes in subcutaneous adipose tissue of beta-adrenergic receptor knockout mice |
| Experiment Type | RNA-Seq | Study Type | WT vs. Mutant |
| Source | ArrayExpress | Curation Date | 2022-10-19 |
| description | Classic brown fat and inducible beige fat both dissipate chemical energy in the form of heat through the actions of mitochondrial uncoupling protein 1. This nonshivering thermogenesis is crucial for mammals as a defense against cold and obesity/diabetes. Cold is known to act indirectly through the sympathetic nervous systems and beta-adrenergic signaling, but here we report that cold temperature can directly activate a thermogenic gene program in adipocytes independent of beta-adrenergic signaling. |
