| Experiment Id | GSE21524 | Name | HORMAD1 mutation disrupts synaptonemal complex formation and chromosomal segregation in fertilized eggs |
| Experiment Type | transcription profiling by array | Study Type | WT vs. Mutant |
| Source | GEO | Curation Date | 2022-10-31 |
| description | Hormad1 encodes a protein that contains a HORMA domain, and unlike Mad2, Hormad1 expression is germ cell specific. We discovered that both male and female are infertile, and HORMAD1 has important function in synaptonemal complex formation, sex chromosome inactivation during spermatogenesis and chromosome segregation in meiosis. RNA isolated from wild-type and Hormad1-/- 2-week-old testes was used for performing Illumina BeadChip MouseWG-6 2.0 arrays. Three replicates per genotype were performed. |
