| Experiment Id | GSE181594 | Name | Relative gene expression of the lateral choroid plexus isolated from Abhd2+/+ and Abhd2-/- mice |
| Experiment Type | RNA-Seq | Study Type | WT vs. Mutant |
| Source | GEO | Curation Date | 2023-02-07 |
| description | Electrophysiological studies of mouse choroid plexus show potentiation of the Kir7.1 channel by progesterone (P4). The choroid plexus (CP) epithelium contains several membrane-bound progesterone receptors that could potentially mediate the cell response to P4. Interestingly, we found that the recently characterized progesterone receptor alpha/beta hydrolase domain-containing protein 2 (ABHD2; Miller et al., 2016) is also highly expressed in the CP. ABHD2 has been shown to regulate ion channel activation in human sperm cells by breaking down the endocannabinoid 2-arachidonoylglycerol in the cell membrane (Miller et al., 2016). However, CPECs isolated from global Abhd2 knockout mice that were generated in our lab (Ida Bjorkgren, 2019) showed similar expression and activation of Kir7.1 as cells from wild type animals, thus negating any possible effect of the receptor on Kir7.1 activation. For gene expression analyses of the mouse choroid plexus, the lateral chroid plexuses (LCPs) of adult Abhd2+/+ (wt) males (n=3) and females (n=3) and of Abhd2-/- (hoz) males (n=3) and females (n=3) were used. |
