| Experiment Id | GSE225065 | Name | Effect of LRP1 deletion in vascular mural cells and APOE gentotype on gene expression in mouse brains |
| Experiment Type | RNA-Seq | Study Type | WT vs. Mutant |
| Source | GEO | Curation Date | 2023-08-02 |
| description | To investigate the apoE isoform-dependent role of vascular mural cell (VMC)-LRP1, we generated VMC-specific LRP1 knockout mice (smLrp1-/-), followed by breeding these mice with either APOE3-targeted replacement (TR) or APOE4-TR mice We then performed gene expression profiling analysis using data obtained from RNA-seq of cortical samples from 4 different mouse models Comparative gene expression profiling analysis of RNA-seq data for VMC-LRP1 deficiency in the presence of apoE3 or apoE4 |
