| Experiment Id | GSE231405 | Name | Single-cell transcriptome profiles of wild-type and IRF8KO microglia [scRNA-seq] |
| Experiment Type | RNA-Seq | Study Type | WT vs. Mutant |
| Source | GEO | Curation Date | 2025-01-30 |
| description | The role of the lineage-determining transcription factor IRF8 in microglia remains unelucidated. We analyzed the transcriptome diversity of wild-type and IRF8KO microglia. Deep-sequencing and subsequent differential analysis revealed the significance of the IRF8-dependent transcription on microglial heterogeneity and self-renewing. This study provides a novel insight into understanding IRF8-mediated transcriptional programs in microglia. Transcriptome profiles of adult WT and IRF8KO microglia were analyzed at a single-cell level using 10xGenomics. |
