| Experiment Id | GSE158202 | Name | Cmarr/miR-540-3p axis promotes cardiomyocyte maturation transition by orchestrating Dtna expression |
| Experiment Type | RNA-Seq | Study Type | Baseline |
| Source | GEO | Curation Date | 2023-07-12 |
| description | Here, our study showed that a heart-rich lncRNA, Cmarr, which is specifically upregulated during heart development, promoted the maturation transition of ESC-CMs. Cmarr interacted with miR-540-3p to increase the expression of Dtna (a key component of DGC), thus served as a new regulator of the DGC-YAP complex and cardiomyocyte maturation. Our study further identified that Cmarr could recover Dtna expression in the MI heart and attenuate the cardiac remodeling. RNA-seq and miRNA-seq of heart tissues |
