| Experiment Id | GSE144427 | Name | Transcriptome analysis of Chx10-Cre Rb1/p107 and Chx10-Cre Rb1/p107/Hells P21 retinae |
| Experiment Type | RNA-Seq | Study Type | WT vs. Mutant |
| Source | GEO | Curation Date | 2023-09-05 |
| description | We used novel genetically engineered mouse models to investigate the role of HELLS during tumorigenesis. Loss of HELLS drastically decreased the incidence of retinoblastoma, delayed tumor progression, and increased overall survival. Retinae from Rb1/p107 DKO and Rb1/p107/Hells TKO mice at postnatal day 21 were analyzed for gene expression using RNA-seq. Retinal mRNA profiles of 21-day-old Chx10-Cre Rb1/p107 and Chx10-Cre Rb1/p107/Hells mice were generated by deep sequencing, in triplicate, using Illumina HiSeq 4000. |
