| Experiment Id | GSE32929 | Series Id | E-GEOD-32929 |
| Name | Expression data from Ezh2-null erythrocyte/megakaryocyte progenitor (MEP) | Experiment Type | transcription profiling by array |
| Study Type | WT vs. Mutant | Source | GEO |
| Curation Date | 2023-11-14 |
| description | The polycomb group (PcG) proteins function in gene silencing through histone modifications. They form chromatin-associated multiprotein complexes, termed polycomb repressive complex (PRC) 1 and PRC2. These two complexes work in a coordinated manner in the maintenance of cellular memories through transcriptional repression of target genes. EZH2 is a catalytic component of PRC2 and trimethylates histone H3 at lysine 27 to transcriptionally repress the target genes. PcG proteins have been characterized as general regulators of stem cells, but recent works also unveiled their critical roles in cancer. Wild type and Ezh2 null MEP from fetal liver and adult bone marrow |
