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HT Experiment :

Experiment Id  GSE75579 Name  Effect of loss of Jmjd1c on normal hematopoiesis
Experiment Type  RNA-Seq Study Type  WT vs. Mutant
Source  GEO Curation Date  2024-04-12
description  Analysis of gene expression profile of LSK (Lin-Sca-1+ c-Kit+) isolated from Jmjd1c f/f Vav1Cre or Vav1Cre controls. Loss of Jmjd1c minimally affected HSC in homeostatsis while impairs HSC function in response to stress such as transplantation and 5-Fu treatment. These results provide insight into the role of Jmjd1c in normal hematopoiesis. LSK cells were isolated from bone marrow of seven weeks old Jmjd1c f/f Vav1Cre or Vav1Cre controls mice by flow activated cell sorting and subjected to RNA-seq.
  • variables:
  • genotype,
  • bulk RNA-seq

1 Publications

Trail: HTExperiment

7 Samples

Trail: HTExperiment