Experiment Id | GSE168379 | Name | Analysis of Differentially Expressed Genes in sorted CD4+ CD8+ double positive (DP) thymocytes from wild type (WT) and NSRP1CD4Cre (KO) mice |
Experiment Type | RNA-Seq | Study Type | WT vs. Mutant |
Source | GEO | Curation Date | 2024-04-18 |
description | NSrp70 deficiency (NSRP1f/fCD4Cre) profoundly perturbed the late development of DP thymocytes, leading to a significant reduction of single positive (SP) cells in the thymus and peripheral lymphoid tissues. To gain further insight how NSrp70 controls thymocyte development from DP stage, we performed RNA-seq analysis after sorting DP thymocytes from WT and Nsrp1 cKO mice. Gene profiles differentially expressed in NSRP1-deficient DP thymocytes compare to wild-type thymocytes |