| Experiment Id | GSE184901 | Name | Neuronal Dot1ll is a broad mitochondrial gene-repressor associated with human brain aging via H3K79 hypermethylation |
| Experiment Type | RNA-Seq | Study Type | WT vs. Mutant |
| Source | GEO | Curation Date | 2024-06-17 |
| description | Role of Dot1l in the transcriptional programming of midbrain dopamine neurons Examination of three groups: 1) Pitx3-Cre/+;Dot1l-+/+;Rosa-lox-stop-lox-YFP 2) Pitx3-Cre/+;Dot1l-Floxed/+;Rosa-lox-stop-lox-YFP 3) Pitx3-Cre/+;Dot1l-Floxed/Floxed/;Rosa-lox-stop-lox-YFP. Material is FACS sorted (YFP) to isolated the Pitx3-Cre positive cells (YFP positive) (midbrain dopamine neurons) for differential gene expression analysis at developmental stage E15.75. |
