| Experiment Id | GSE196445 | Name | Dyrk1a dosage effects on the transcriptome of embryonic hearts from the Dp1Tyb mouse model of Down syndrome using bulk RNAseq |
| Experiment Type | RNA-Seq | Study Type | WT vs. Mutant |
| Source | GEO | Curation Date | 2024-06-24 |
| description | We performed bulk RNAseq on whole hearts from E13.5 Dp1Tyb embryos and from wild-type littermates, as well as hearts from E13.5 Dp1TybDyrk1a+/+/- embryos and wild-type littermates. Analysis showed the expected increased expression of the Hsa21-orthologous genes on Mmu16 that are present in 3 copies. Gene set enrichment analysis identified pathways that are altered in Dp1Tyb hearts. Some of these changes were dependent on 3 copies of Dyrk1a. RNAseq on 5 E13.5 Dp1Tyb embryonic hearts and 5 wild-type littermate embryonic hearts, and on 5 E13.5 Dp1TybDyrk1a+/+/- embryonic hearts and 5 wild-type littermate embryonic hearts. |
