Experiment Id | GSE223879 | Name | RREB1 Regulates Neuronal Proteostasis and Microtubule Network Function [RNA-seq] |
Experiment Type | RNA-Seq | Study Type | WT vs. Mutant |
Source | GEO | Curation Date | 2024-07-09 |
description | To establish molecular pathways disrupted by loss of RREB1 in Purkinje cells, RNA-seq was performed on mRNA isolated from Purkinje cells and differential expression analysis was performed. Cerebella from 3 Rpl22fl/+;PCP2-Cre and 4 Rpl22fl/+;PCP2-CRE;nm3888-/- mice were collected. HA tagged ribosomes were immunoprecipitated from fresh tissue and nascent mRNA transcripts were isolated . |