| Experiment Id | GSE190947 | Name | Hepatocyte RNA-seq analysis in liver-specific XBP1 knockout mice fed a high fat sugar diet |
| Experiment Type | RNA-Seq | Study Type | WT vs. Mutant |
| Source | GEO | Curation Date | 2024-07-09 |
| description | X-box binding protein 1 (XBP1) is a key component of the unfolded protein response (UPR) and plays important roles in the pathogenesis of nonalcoholic fatty liver diseases (NAFLD). Mice with liver-specific XBP1 deletion developed great liver injury and fibrosis in a dietary model of NAFLD. This project is to investigate hepatocyte-specific transcriptome profiling in XBP1-deficient mice fed a high fat sugar diet. Liver-specific Xbp1 deficient mice or flox controls were fed either regular chow or a high fat sugar (HFS) diet for up to 6 weeks. Hepatocytes were isolated at the conclusion of the experiments and RNA was extracted with Trizol. Samples in HFS diet cohorts (n=6) were pooled into three replicates. |
