| Experiment Id | GSE190043 | Name | Single-cell RNA sequencing on the testis from the rete testis-specific Sox17 conditional knockout (cKO) mice and the controls at P14. |
| Experiment Type | RNA-Seq | Study Type | WT vs. Mutant |
| Source | GEO | Curation Date | 2023-03-09 |
| description | In mammalian testes, a valve-like structure called Sertoli valve is located at the border region of the seminiferous tubule and the rete testis. Having identified Sox17 in the rete testis as a positive regulator of the valve formation, this study aim to elucidate the mechanism of Sox17-expressing rete testis to modulate the testicular homeostasis. Our scRNA-seq data demonstrate the altered gene expression levels of several growth factors in Sox17-depleted rate testis epithelia, and highlighted the altered proportion of Sertoli cells located around the proximal part of the testis. This study provides a comprehensive profile of the proximal part of the testis including the rete testis and Sertoli valve for the first time, and further illustrate the functional role of the Sox17+ rete tesits to orchestrate the testicular homeostasis. Comparison of mRNA profiles of the cell located at the proximal part of the testis collected from the rete testis-specific Sox17 conditioinal knockout (cKO) mice and the controls. |
