| Experiment Id | E-GEOD-60691 | Series Id | GSE60691 |
| Name | Disrupting SUMOylation potentiates transactivation function and ameliorates polyglutamine AR-mediated disease | Experiment Type | RNA-Seq |
| Study Type | WT vs. Mutant | Source | ArrayExpress |
| Curation Date | 2019-03-07 |
| description | Our findings demonstrate beneficial effects of enhancing transactivation function of the ligand-activated polyQ AR and indicate that the SUMOylation pathway may provide new targets for therapeutic intervention. We mutated conserved lysines in the polyQ AR that are targeted by SUMO, a modification that inhibits AR transactivation function. |
