| Experiment Id | GSE146894 | Name | Oocyte developmental competence is instructed by H3.3 chaperone Hira complex |
| Experiment Type | RNA-Seq | Study Type | WT vs. Mutant |
| Source | GEO | Curation Date | 2023-10-10 |
| description | Reproductive success begins with a healthy egg (a competent oocyte). An oocyte acquires its developmental competence during oogenesis in preparation for accomplishing the critical developmental transition from completion of meiosis to initiation of early embryogenesis. Here we comprehensively characterised the maternal role of major subunits of Hira (i.e. Hira, Cabin1 and Zscan4) during oocyte-to-embryo transition. GV oocytes from Hira or Cabin1 Het and KO mice, 2 cell embryos from Cabin 1 Het and KO mice, 2 cell embryos with Zscan4 overexpression were pooled for RNA sequencing analysis. GV oocytes from Cabin1 Het and KO mice (C57BL/6) were pooled for ATAC sequencing analysis. |
