| Experiment Id | GSE198167 | Name | RNA-seq of cochlea in mice with a frameshift mutation in the reading frame of thyroid hormone receptor alpha1 |
| Experiment Type | RNA-Seq | Study Type | WT vs. Mutant |
| Source | GEO | Curation Date | 2025-01-10 |
| description | Thyroid hormone is known to be required for inner ear development. The influence of the thyroid hormone receptor alpha1 is however unclear, as most previous studies point to a predominant function of the TRbeta1/2 isotypes. We report a RNA-seq analysis which completes a full histological and functional analysis showing that mice carrying a mutation of the TRalpha1 receptor have mild alteration of inner ear. Whole inner ear RNA was extracted from heterozygous mutant mice carrying a frameshift mutation which alters the function of TRalpha1. These RNA were compared to RNA extracted from wild-type littermates. |
