| First Author | Gradwell MA | Year | 2022 |
| Journal | Pain | Volume | 163 |
| Issue | 3 | Pages | e432-e452 |
| PubMed ID | 34326298 | Mgi Jnum | J:365769 |
| Mgi Id | MGI:8188250 | Doi | 10.1097/j.pain.0000000000002422 |
| Citation | Gradwell MA, et al. (2022) Diversity of inhibitory and excitatory parvalbumin interneuron circuits in the dorsal horn. Pain 163(3):e432-e452 |
| abstractText | Parvalbumin-expressing interneurons (PVINs) in the spinal dorsal horn are found primarily in laminae II inner and III. Inhibitory PVINs play an important role in segregating innocuous tactile input from pain-processing circuits through presynaptic inhibition of myelinated low-threshold mechanoreceptors and postsynaptic inhibition of distinct spinal circuits. By comparison, relatively little is known of the role of excitatory PVINs (ePVINs) in sensory processing. Here, we use neuroanatomical and optogenetic approaches to show that ePVINs comprise a larger proportion of the PVIN population than previously reported and that both ePVIN and inhibitory PVIN populations form synaptic connections among (and between) themselves. We find that these cells contribute to neuronal networks that influence activity within several functionally distinct circuits and that aberrant activity of ePVINs under pathological conditions is well placed to contribute to the development of mechanical hypersensitivity. |
