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Publication : Survey of spiking in the mouse visual system reveals functional hierarchy.

First Author  Siegle JH Year  2021
Journal  Nature Volume  592
Issue  7852 Pages  86-92
PubMed ID  33473216 Mgi Jnum  J:364284
Mgi Id  MGI:6710201 Doi  10.1038/s41586-020-03171-x
Citation  Siegle JH, et al. (2021) Survey of spiking in the mouse visual system reveals functional hierarchy. Nature 592(7852):86-92
abstractText  The anatomy of the mammalian visual system, from the retina to the neocortex, is organized hierarchically(1). However, direct observation of cellular-level functional interactions across this hierarchy is lacking due to the challenge of simultaneously recording activity across numerous regions. Here we describe a large, open dataset-part of the Allen Brain Observatory(2)-that surveys spiking from tens of thousands of units in six cortical and two thalamic regions in the brains of mice responding to a battery of visual stimuli. Using cross-correlation analysis, we reveal that the organization of inter-area functional connectivity during visual stimulation mirrors the anatomical hierarchy from the Allen Mouse Brain Connectivity Atlas(3). We find that four classical hierarchical measures-response latency, receptive-field size, phase-locking to drifting gratings and response decay timescale-are all correlated with the hierarchy. Moreover, recordings obtained during a visual task reveal that the correlation between neural activity and behavioural choice also increases along the hierarchy. Our study provides a foundation for understanding coding and signal propagation across hierarchically organized cortical and thalamic visual areas.
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