| First Author | Jin Y | Year | 2019 |
| Journal | Hear Res | Volume | 377 |
| Pages | 247-259 | PubMed ID | 31003036 |
| Mgi Jnum | J:310494 | Mgi Id | MGI:6762736 |
| Doi | 10.1016/j.heares.2019.04.002 | Citation | Jin Y, et al. (2019) Deletion of Brg1 causes stereocilia bundle fusion and cuticular plate loss in vestibular hair cells. Hear Res 377:247-259 |
| abstractText | Brg1 is an ATPase subunit of the SWI/SNF chromatin-remodeling complex, and it is indispensable for the development and homeostasis of various organs. Conditional deletion of Brg1 in cochlea hair cells (HCs) leads to multiple structural defects and profound deafness. However, the premature death of Brg1-deficient cochlea HCs hindered further study of the role of Brg1. In contrast to cochlea HCs, Brg1-deficient vestibular HCs survived for a long time. Therefore, HC apical structure and vestibular function were examined in inner HC-specific conditional Brg1 knockout mice. Vestibular HCs exhibited fused and elongated stereocilia bundles after deletion of Brg1, and the cuticular plate was absent in most HCs with fused stereocilia bundles. HC loss was observed in conditional Brg1 knockout mice at the age of 12 months. Morphological defects and HC loss were primarily restricted in the striolar region of the utricle and saccule and in the central region of ampulla. The behavioral tests revealed that Brg1 deletion in HCs caused vestibular dysfunction in older adult mice. These results suggest that Brg1 may play specific roles in the maintenance of the HC stereocilia bundle and the cuticular plate. |
