| First Author | Xu Q | Year | 2019 |
| Journal | J Dent Res | Volume | 98 |
| Issue | 6 | Pages | 689-697 |
| PubMed ID | 30971171 | Mgi Jnum | J:379998 |
| Mgi Id | MGI:8279080 | Doi | 10.1177/0022034519839438 |
| Citation | Xu Q, et al. (2019) Mechanoadaptive Responses in the Periodontium Are Coordinated by Wnt. J Dent Res 98(6):689-697 |
| abstractText | Despite an extensive literature documenting the adaptive changes of bones and ligaments to mechanical forces, our understanding of how tissues actually mount a coordinated response to physical loading is astonishingly inadequate. Here, using finite element (FE) modeling and an in vivo murine model, we demonstrate the stress distributions within the periodontal ligament (PDL) caused by occlusal hyperloading. In direct response, a spatially restricted pattern of apoptosis is triggered in the stressed PDL, the temporal peak of which is coordinated with a spatially restricted burst in PDL cell proliferation. This culminates in increased collagen deposition and a thicker, stiffer PDL that is adapted to its new hyperloading status. Meanwhile, in the adjacent alveolar bone, hyperloading activates bone resorption, the peak of which is followed by a bone formation phase, leading ultimately to an accelerated rate of mineral apposition and an increase in alveolar bone density. All of these adaptive responses are orchestrated by a population of Wnt-responsive stem/progenitor cells residing in the PDL and bone, whose death and revival are ultimately responsible for directly giving rise to new PDL fibers and new bone. |
