| First Author | Han J | Year | 2021 |
| Journal | Int J Biol Sci | Volume | 17 |
| Issue | 3 | Pages | 861-868 |
| PubMed ID | 33767594 | Mgi Jnum | J:378265 |
| Mgi Id | MGI:8279111 | Doi | 10.7150/ijbs.56091 |
| Citation | Han J, et al. (2021) PTEN-mediated AKT/beta-catenin signaling enhances the proliferation and expansion of Lgr5+ hepatocytes. Int J Biol Sci 17(3):861-868 |
| abstractText | Rationale: Compelling evidence suggests that Lgr5+ hepatocytes repair liver damage by promoting the regeneration of hepatocytes and ductal cells in the case of liver injury. The PTEN-mediated AKT/beta-catenin signaling plays a key role in the regulation of innate immune regulation in the liver. However, the signaling pathways that control Lgr5+ hepatocyte proliferation in the liver remain unclear. Methods: In order to assess the involvement of PTEN-mediated AKT/beta-catenin signaling in the expansion of Lgr5+ hepatocytes upon liver injuries, the Lgr5-CreER; Rosa-mTmG lineage tracing system was used to target Lgr5+ hepatocytes. Results: The tracing of Lgr5+ hepatocytes showed that PTEN deletion and beta-catenin activation significantly promoted the proliferation of Lgr5+ hepatocytes. In converse, the simultaneous inhibition of PTEN and beta-catenin limited Lgr5+ hepatocyte proliferation in the liver. Our findings provide an insight into understanding how PTEN-mediated AKT/beta-catenin signaling regulates the proliferation of Lgr5+ hepatocytes. Conclusion: The outcomes can improve the application potential of Lgr5+ hepatocytes in the treatment of liver injury diseases and provide a new treatment option for liver cancer. |
