| First Author | Bex J | Year | 2026 |
| Journal | J Exp Med | Volume | 223 |
| Issue | 5 | PubMed ID | 41885768 |
| Mgi Jnum | J:390799 | Mgi Id | MGI:8398373 |
| Doi | 10.1084/jem.20240764 | Citation | Bex J, et al. (2026) Basophils drive the resolution and promote wound healing in adult and aged mice. J Exp Med 223(5) |
| abstractText | An active resolution is critical to control the duration of inflammation and limit its pathological consequences. Defects in resolution during wound healing allow the emergence of chronic wounds, a common complication in the elderly. Here, we show that basophils accumulate in perivascular areas at the periphery of mouse skin wounds for at least 3 wk, during both the inflammation and resolution phases of wound healing. Depletion of basophils induces an increased secretion of inflammatory molecules, accumulation and activation of pro-inflammatory leukocytes, and delays the wound healing response. Basophils particularly promote epidermal differentiation towards homeostasis. These properties are particularly driven by basophil-derived IL-4. Unexpectedly, aged mice basophils more potently infiltrate skin wounds to promote inflammation resolution. Thus, basophils are pro-resolution cells during an essential biological process such as skin wound healing. Unraveling basophil pro-resolution properties may reveal new strategies to fight chronic wounds in the elderly. |
