| First Author | Folkard R | Year | 2026 |
| Journal | Cereb Cortex | Volume | 36 |
| Issue | 3 | PubMed ID | 41874969 |
| Mgi Jnum | J:385514 | Mgi Id | MGI:8315385 |
| Doi | 10.1093/cercor/bhag029 | Citation | Folkard R, et al. (2026) Corticothalamic layer 6 controls cortical activity and thalamic firing mode in a bidirectional manner. Cereb Cortex 36(3) |
| abstractText | Corticothalamic layer 6 modulates information flow between cortical and thalamic circuits. Previous research reported contrasting inhibitory or excitatory effects of corticothalamic layer 6 on cortical dynamics, potentially reflecting technological discrepancies or physiological differences in corticothalamic layer 6 function. To resolve these discrepancies, we combined translaminar, multi-channel in vivo electrophysiology in the primary somatosensory cortex of anesthetized mice with optogenetic stimulation across a range of stimulation regimes to manipulate firing rate and spiking statistics of corticothalamic layer 6. Increasing corticothalamic layer 6 firing rates exerted a transition from inhibition to excitation across cortical layers. Furthermore, corticothalamic layer 6 activity imparted population synchrony onto distinct cortical subpopulations, independent of changes in overall corticothalamic layer 6 activity. In the thalamus, corticothalamic layer 6 modulated thalamic bursting in a bidirectional manner, dependent on optogenetic stimulation frequency. These results demonstrate that corticothalamic layer 6 in primary somatosensory cortex can bidirectionally modulate both cortical firing and thalamic firing mode, elucidating a more nuanced function of somatosensory corticothalamic layer 6 in thalamic and cortical signaling than previously recognized. |
