| First Author | Tease C | Year | 1993 |
| Journal | Mouse Genome | Volume | 91 |
| Issue | 1 | Pages | 115 |
| Mgi Jnum | J:4294 | Mgi Id | MGI:52790 |
| Citation | Tease C (1993) A cytogenetically visible, radiation-induced deletion on chromosome 1. Mouse Genome 91(1):115 |
| abstractText | Research News: 2. A cytogenetically visible, radiation-induced deletion on chromosome 1. Among the progeny of a C3H/HeH x 101/H female given 1 Gy of X-rays was a male with a white head dot and white patch on the thorax, The animal was also slightly smaller than its littermates at weaning weighing 8.51 gm compared with an average of 10.99 gm for its 3 female sibs. Although the male was mated to 3 C3H/HeH x 101/H females over a period of approximately 8 months, no litters resulted. At 9 months of age the male became sick and was killed for chromosome preparations from the testes and bone marrow. The testes were relatively small, the left weighed 33.0 mg, the right 37.5 mg. Analysis of 25 metaphase I stage spermatocytes provided no evidence of reciprocal translocation heterozygosity. Examination of G-banded chromosomes from bone marrow cells showed that the male did however carry a deletion of part of the proximal end of chromosome 1. The deletion appeared to involve part of band C1, and all of C2 and C3. Measurements from photographs of 10 cells indicated deletion of approximately 12% of chromosome 1. The phenotypic effects in the mutant male would therefore appear to be a consequence of this deletion. Two other cytogenetically visible deletions of chromosome 1 have previously been identified: splotch-retarded (Spr) which involves band C4 (Evans et a1 MNL 81:66, 1988); and domed head (Dmh), a large deletion that stretches from C5 to E4 (Cattanach Genetics, 3:56, 1993). The present mutant extends proximally the region of chromosome 1 that can be deleted and still be consistent with viability (Tease). (This study was supported in part by Euratom contract Bi6-143). |
