| First Author | Yoshida MC | Year | 1984 |
| Journal | Cytogenet Cell Genet | Volume | 37 (1-4) |
| Pages | 613 (Abstr.) (399-616) | Mgi Jnum | J:4913 |
| Mgi Id | MGI:53393 | Citation | Yoshida MC (1984) Assignment of GDH and FUCA to rat chromosome 5: evidence for homologous linkage groups in rat, mouse and man (Abstracts of meeting presentations: Human gene mapping 7, Los Angeles Conference (1983) Seventh International Workshop on Human Gene Mapping). Cytogenet Cell Genet 37 (1-4):613 (Abstr.) (399-616) |
| abstractText | Assignment of GDH and FUCA to rat chromosome 5: evidence for homologous linkage groups in rat, mouse and man. M.C. Yoshida. Chromosome Research Unit, Faculty of Science, Hokkaido University, Sapporo. The genes for AK2, EN01, PGD and PGM1 have been assigned to the short arm of human chromosome 1 and mouse chromosome 4. In the rat homologous forms of the genes are located on chromosome 5 (Yoshida, Proc. Jpn. Acad. 55:403, 1979; HGM6, 1982). The gene coding for GDH is syntenic with those genes in mouse and man, and located on mouse chromosome 4 and human chromosome 1. In the man FUCA and GDH are linked and located on lp. These data suggest that in the rat the genes coding for FUCA and GDH may be linked and located on chromosome 5. To test this hypothesis rat x mouse hybrid clones were analyzed for the expression of FUCA and GDH. Enzyme and cytogenetic data show that FUCA and GDH segregated concordantly with the rat 5. Comparative banding studies suggested that chromosome homology between rat 5 and mouse 4 is extensive, indicating that chromosome and linkage homologies are conserved in the rat, mouse and man. |
