| First Author | Threadgill DS | Year | 1989 |
| Journal | Cytogenet Cell Genet | Volume | 51 |
| Pages | 1090-1091 (Abstr.) | Mgi Jnum | J:12512 |
| Mgi Id | MGI:60757 | Citation | Threadgill DS, et al. (1989) Comparative mapping of HSA 21/MMU 16 homologs in the bovine. Cytogenet Cell Genet 51:1090-1091 (Abstr.) |
| abstractText | Full text of Abstract: Comparative mapping of HAS 21/MMU 16 hoologs in the bovine. (A2662). DS Threadgill1, JE Womack1, JP Kraus2, SA Krawetz3; 1Dept. of Veterinary Pathology, Texas A&M University, College Station, TX 77843; 2 Dept. of Human Genetics, Yale University School of Medicine, New Haven, CT 06510; 3Wayne State Univ., Detroit, MI Homologs of genes located on human (HSA) chromosome 21 are located on mouse (MMU) chromosomes 10, 16, and 17. Previous studies have indicated that bovine syntenic group U10 contains several homologous genes from HSA 21, MMU 16, and MMU 17 including SOD1, IFNBR, PRGS, PAIS, SST and CRYA1. This study, utilizing a bovine-hamster hybrid somatic cell panel, was undertaken to determine the extent of similarity between bovine syntenic group U10 and HSA 21, MMU10, 16 and 17. The genes evaluated for their syntenic relationship in cattle were PRM1 (HSA 16, MMU16), CBS (HAS 21, MMU 17), CD18, S100B, COL6A1, COL6A2, (HAS 21, MMU 10), GAP43 (HAS 3, MMU 16), APP, ETS2 (HAS 21, MMU 16), PFKL (HAS 21, MMU ?), and TF (HAS 3, MMU 9). Of the genes evaluated for synteny, only PRM1 (HAS 16) was asyntenic with bovine syntenic group U10. Thus, the bovine chromosome represented by syntenic group U10 carries homologs of at least 15 genes mapped in mice and humans. Specifically, all HSA 21 homologs mapped in cattle are syntenic. Additionally, three HSA 3 genes, two of which have homologs on MMU 16, map to bovine syntenic group U10. The assignment of the third HSA 3 gene, TF, to bovine syntenic group U10 differs from the syntenic relationship of TF wilh ACY1 found in mice and humans. However, linkage of TF and SOD1 in the marsupial Sminthopsis crassicaudata implies the synteny of TF with SOD1 found in cattle may be the ancestral arrangement. |
