| First Author | Brown RM | Year | 1989 |
| Journal | Cytogenet Cell Genet | Volume | 51 |
| Pages | 970 (Abstr.) | Mgi Jnum | J:12521 |
| Mgi Id | MGI:60766 | Citation | Brown RM, et al. (1989) An homologous locus to the human X-linked pyruvate dehydrogenase E1-alpha subunit gene is located at the distal end of the mouse X Chromosome. Cytogenet Cell Genet 51:970 (Abstr.) |
| abstractText | Full text of Abstract: An homologous locus to the human X-linked pyruvate dehydrogenase E1alpha subunit gene is located at the distal end of the mouse X chromosome. (A2207). RM Brown, H-HM Dahl, GK Brown; Murdoch Institute, Royal Children's Hospital, Melbourne, Australia 3052 In situ hybridization using a cDNA probe for the E1alpha subunit of the human pyruvate dehydrogenase (PDH) complex has shown that the corresponding mouse gene is located close to the terminal region of the mouse X chromosome in the region F3-ter. It is there-fore physically linked to the genes for steroid sulfatase and hypophosphatemia. The localization of the PDH E1alpha gene to this region is of particular interest from an evolutionary point of view as it is some distance from the mdx locus. In contrast, the human PDH E1alpha gene, located at Xp22.1-p22.2, is physically much closer to the homologous DMD locus at Xp21. In addition to the X-linked PDH E1alpha locus, there is at least one autosomal locus in the mouse and this is located on chromosome 19. This is analogous to the human autosomal PDH E1alpha locus on chromosome 4 and is also expressed only in adult testis. |
