| First Author | Barendse W | Year | 1991 |
| Journal | Cytogenet Cell Genet | Volume | 58 |
| Pages | 2123 (Abstr.) | Mgi Jnum | J:15864 |
| Mgi Id | MGI:63973 | Citation | Barendse W, et al. (1991) Comparison of gene order of three bovine chromosomal segments to the human. Cytogenet Cell Genet 58:2123 (Abstr.) |
| abstractText | Full text of Abstract. Abstracts for the committee on comparative gene mapping. Comparison of gene order of three bovine chromosomal segments to the human. Barendse W(1), Armitage SM(1), Womack JE(2), Hetzel DJ(1); 1 CSIRO, Tropical Animal Production, Box 5545, Rockhampton Mail Centre, Queensland, Australia 4702; 2 Dept of Veterinary Pathology, Texas A&M University, College Station, TX 77843, USA We have analysed genetic linkage between loci on three bovine chromosomal segments - one each on chromosomes 14, 15, and 19 - using as family material the CSIRO Cattle Reference Pedigrees and found substantial conservation of gene order between humans and cattle. The lods for the segregation of alleles were calculated for all pairwise comparisons of linkage loci using LIPED. Preliminary map order was obtained by placing loci together with the smallest recombination fractions. Then a multipoint analysis was performed to determine the most likely order. The loci on chromosome 14 have the order CA2 (Carbonic Anhydrase II - pHCAII38.3)_0.28_MOS (v-mos oncogene homolog - pMP)_0.23_CRF (Corticotrophin releasing factor -oCRF)_0.11_MYC (v-myc oncogene homolog - pHSR-l)_0.00_TG (Thyroglobulin - pbTg2.8). The loci on chromosome 15 have the order PTH (Parathyroid hormone) _0.42_HBB (Hemoglobin beta)_0.14_FSHB (Follicle stimulating hormone beta subunit). The loci on chromosome 19 have the order PRKCA (Protein Kinase C alpha - phPKC - alpha7)_0.00_HOX2 (homeobox region 2 - pMo4.1)_0.28_GH (Growth Hormone beta subunit - )_0.28_GAA (acid alpha Glucosidase - ).When these orders are compared to humans, CA2 and PTH do not occur in the same positions in both cattle and humans. |
