| First Author | Davisson MT | Year | 1977 |
| Journal | Mouse News Lett | Volume | 57 |
| Pages | 19-20 | Mgi Jnum | J:23180 |
| Mgi Id | MGI:71356 | Citation | Davisson MT, et al. (1977) Inversions. Mouse News Lett 57:19-20 |
| abstractText | Full text of MNL contribution: New Chromosomal Aberrations: 1. Inversions. A new inversion, In(18)21Rk, involving almost all of Chr 18 has been recovered in a son of a TEM-treated male. The proximal breakpoint is within the pericentric heterochromatin and the transposition of about one-half of the heterochromatic segment to the distal portion of the chromosome has been confirmed by C-banding. Testicular sections resemble those of partially sterile males, but there is no reduction in fertility. We find no meiotic or mitotic evidence for the presence of a translocation. Heterozygotes have bridges in 47% of their first meiotic anaphases. Preliminary linkage tests between Chr 18 markers and the inversion showed 6/13 recombinants with syfp and 5/7 recombinants with Tw. Because of the penetrance problem with Tw only Tw/+ mice were tabulated for the recombinational frequency. Although two or three strand double crossovers within the inversion could account for this apparent lack of linkage, our experience with another large inversion has shown at least reduced recombination with all markers along the chromosome. This preliminary linkage data creates some doubt in our minds about assignment of the syfp - bc - Tw linkage group to Chr 18. Another newly induced inversion appears to be linked to hairless on Chr 14. In a backcross, all eleven animals were parental genotypes. This inversion is designated In(14)22Rk. (Davisson, N. Hawes, and Roderick) |
