| First Author | Briles DE | Year | 1976 |
| Journal | Fed Proc | Volume | 35 |
| Pages | 824 (Abstr.) | Mgi Jnum | J:24617 |
| Mgi Id | MGI:72353 | Citation | Briles DE, et al. (1976) Genetic control of non-H-2 linked T-dependent antibody response defects of the BSVS mouse. Fed Proc 35:824 (Abstr.) |
| abstractText | Full text of Abstract: GENETIC CONTROL OF NON-H-2 LINKED T-DEPENDENT ANTIBODY RESPONSE DEFECTS OF THE BSVS MOUSE. D.E. Briles. P.M. Krause and J.M. Davie. Washington Univ. Sch. Med., St. Louis, MO and The Rockefeller University, New York, N.Y. BSVS mice are defective in their immune responses to 2 thymus (T)-dependent antigens, DNP-hemocyanin (H) and streptococcal Group A carbohydrate (GAC), yet respond normally to the T-independent antigens, DNP-ficoll and pneumococcal carbohydrate (phosphorylcholine). In addition, the BSVS responses to DNP-H and GAC are indistinguishable from the responses of thymectomized (Tx) responder mice. Thus, BSVS and Tx-AKR are deficient in the IgG, but not the IgM response to DNP-H. On the other hand, both the IgM and IgG responses to GAC are depressed in BSVS and Tx-AKR mice. To determine whether the defects in the BSVS response to the 2 antigens might involve the same or linked genes, we studied the inheritance of the defects. Immune responses to both antigens were dominant in F1 mice. In the backcross (BSVS x A/J) BSVS mice, there were equal numbers of anti-GAC responder and nonresponder mice, a result consistent with a single gene defect. However, when the backcross mice were immunized with DNP-H there were about 4 high responders to each low responder, a result consistent with more than one defective gene. In addition, there was no linkage between the genes controlling responsiveness to the 2 antigens or to either antigen and H-2 type, allotype, or hemoglobin type. Thus, T-dependent responses appear to involve multiple levels of genetic control. Supported by the Public Health Service and several tobacco companies. |
