| First Author | Festing MFW | Year | 1987 |
| Journal | Mouse News Lett | Volume | 79 |
| Pages | 24 | Mgi Jnum | J:24737 |
| Mgi Id | MGI:72468 | Citation | Festing MFW (1987) CKB through C3H/Bi Strains. Mouse News Lett 79:24 |
| abstractText | Full text of MNL contribution: CKB Inbr. 50. Agouti. +. Origin: C3H.SW (Ig-1b, H-2b) x C3H (Ig-1a, H-2k), F1 inbred to give CKB. CL Inbr(Fr) 70. Albino: b,c. Origin: stock from Morgan carrying msl (migratory spot lesion, a variable white spot on the retina). Crossed with A/J then inbred with selection for a high incidence of cleft lip (incidence now 25% in viable 17-day embryos). Maint. by Fr, Ksb, Nem. CN Inbr(Nmg) 27. Cinnamon b. Origin: Fa non-inbred obese stock. Inbred from 1976. Maint. by Nmg. CPB-K Inbr(Nmg) 70+16. Steely blue: a,B,d. Origin: Cpb stock of unknown origin, inbred from 1979. Maint. by Nmg. CS Inbr (Nga) 94. Albino a,b,c,b,s. Origin: 1956 from a cross between NBC and SII, both now extinct. Unrelated to IVCS. Maint. by Nga. CT Inbr (Lac) ?+8 . Agouti: +. Origin: ct (curly-tail) mutation arose spontaneously in GFF inbred mice. Backcrossed to CBA an unknown number of times, then bxs of presumed ct/ct homozygotes. Dr. Mary Sellers to Lac in 1985. Expression of the ct gene ranges from spina-bifida causing pre-natal death to various degrees of kinky tail, to complete normality. Maint. by Lac. CTA Inbr. 65. Albino: a,b,c, cts. Origin: Cateract mutation (Ohtori, 1968, Exp. Anim. 17:91-98, Harata M. et a1 1978 J. Genet. 53:147) in a stock of unstated origin. Maintained by Idr. CWD Inbr (Le) 53. Non-agouti dilute: a,d,cw (curly-whiskers). Origin: cw arose in CBA/Cbi at Chester Beatty Res. Inst. To Harwell. Stock T11H from A.G. Searle to J in 1971. Crossed to B6C3Fe-a/aFl then to DBA/2, then inbred. Maint. by Le. CXB- Inbr (By) 91. Set of seven Recombinant Inbred Strains (CXBD,E,G,H,I,J,K) developed by Bailey from a cross of BALB/c x C57BL/6J. Maint. by By. CXS- Inbr Set of 14 recombinant inbred strains developed by A from a cross of BALB/cA x STS/A. Maint. by A. C3H Agouti. Origin. Strong 1920 from a cross between the Bagg albino stock and DBA (see also CBA), with selection for a high incidence of mammary tumours. Now among the most widely used strains. Most substrains have a good reproductive performance. Unfostered sublines (which are now relatively rare since 'SPF' animals have become popular) have a high incidence of mammary tumours (usually > 90% at one year) caused by a virus which is passed from mother to offspring through the milk. The strain should be used with care in behavioural studies as it carries the rd (retinal degeneration) gene and mice are blind from about six weeks of age. Some substrain differences are large, and can not be accounted for solely on the basis of mutation, and must be ascribed either to substantial residual heterozygosity or genetic contamination, though C3H/HeJ is known to differ from C3H/He as a result of a mutation at the Lps locus. C3H/Bi Inbr(Ki) 160. Origin: Strong to Bittner 1931, to Kirschbaum 1952. Differs from He,St and eB/FeJ substrains at the Idh-1, Pgm-1, and Trf. |
