| First Author | Hachisuka J | Year | 2020 |
| Journal | Pain | Volume | 161 |
| Issue | 1 | Pages | 185-194 |
| PubMed ID | 31577643 | Mgi Jnum | J:365820 |
| Mgi Id | MGI:8188285 | Doi | 10.1097/j.pain.0000000000001710 |
| Citation | Hachisuka J, et al. (2020) Selective-cold output through a distinct subset of lamina I spinoparabrachial neurons. Pain 161(1):185-194 |
| abstractText | Spinal projection neurons are a major pathway through which somatic stimuli are conveyed to the brain. However, the manner in which this information is coded is poorly understood. Here, we report the identification of a modality-selective spinoparabrachial (SPB) neuron subtype with unique properties. Specifically, we find that cold-selective SPB neurons are differentiated by selective afferent input, reduced sensitivity to substance P, distinct physiological properties, small soma size, and low basal drive. In addition, optogenetic experiments reveal that cold-selective SPB neurons do not receive input from Nos1 inhibitory interneurons and, compared with other SPB neurons, show significantly smaller inhibitory postsynaptic currents upon activation of Pdyn inhibitory interneurons. Together, these data suggest that cold output from the spinal cord to the parabrachial nucleus is mediated by a specific cell type with distinct properties. |
