| First Author | Murphy MP | Year | 2020 |
| Journal | Nat Med | Volume | 26 |
| Issue | 10 | Pages | 1583-1592 |
| PubMed ID | 32807933 | Mgi Jnum | J:362394 |
| Mgi Id | MGI:6710318 | Doi | 10.1038/s41591-020-1013-2 |
| Citation | Murphy MP, et al. (2020) Articular cartilage regeneration by activated skeletal stem cells. Nat Med 26(10):1583-1592 |
| abstractText | Osteoarthritis (OA) is a degenerative disease resulting in irreversible, progressive destruction of articular cartilage(1). The etiology of OA is complex and involves a variety of factors, including genetic predisposition, acute injury and chronic inflammation(2-4). Here we investigate the ability of resident skeletal stem-cell (SSC) populations to regenerate cartilage in relation to age, a possible contributor to the development of osteoarthritis(5-7). We demonstrate that aging is associated with progressive loss of SSCs and diminished chondrogenesis in the joints of both mice and humans. However, a local expansion of SSCs could still be triggered in the chondral surface of adult limb joints in mice by stimulating a regenerative response using microfracture (MF) surgery. Although MF-activated SSCs tended to form fibrous tissues, localized co-delivery of BMP2 and soluble VEGFR1 (sVEGFR1), a VEGF receptor antagonist, in a hydrogel skewed differentiation of MF-activated SSCs toward articular cartilage. These data indicate that following MF, a resident stem-cell population can be induced to generate cartilage for treatment of localized chondral disease in OA. |
