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Allele : Gt(ROSA)26Sor<tm1(creB)Dwi> gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Douglas J Winton
Primary Identifier  MGI:5486456 Allele Type  Targeted
Attribute String  Recombinase Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  (129S6/SvEvTac x C57BL/6J)F1
Is Recombinase  true Is Wild Type  false
molecularNote  A cassette was constructed with the creB fragment of cre recombinase (codons 60-343) fused to an FKBP dimerization domain by an F2 linker and included a polyadenylation sequence. This cassette was cloned into a plasmid containing Gt(ROSA)26Sor homology sequences. The linearized plasmid was introduced into ES cells and by homologous recombination the creB sequence was inserted into the Gt(ROSA)26Sor locus. When crossed to mice expressing the creA sequence, the two fragments will dimerize in presence of AP20187 and a functional cre protein will be produced.
  • mutations:
  • Insertion
  • synonyms:
  • Rosa26-creB,
  • Rosa26-creB
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Trail: Allele

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