| First Author | Antonica F | Year | 2019 |
| Journal | Dev Biol | Volume | 450 |
| Issue | 2 | Pages | 132-140 |
| PubMed ID | 30940540 | Mgi Jnum | J:363848 |
| Mgi Id | MGI:6315466 | Doi | 10.1016/j.ydbio.2019.03.016 |
| Citation | Antonica F, et al. (2019) Concerted cell divisions in embryonic visceral endoderm guide anterior visceral endoderm migration. Dev Biol 450(2):132-140 |
| abstractText | Migration of Anterior Visceral Endoderm (AVE) is a critical symmetry breaking event in the early post-implantation embryo development and is essential for establishing the correct body plan. Despite much effort, cellular and molecular events influencing AVE migration are only partially understood. Here, using time-lapse live imaging of mouse embryos, we demonstrate that cell division in the embryonic visceral endoderm is coordinated with AVE migration. Moreover, we demonstrate that temporal inhibition of FGF signalling during the pre-implantation specification of embryonic visceral endoderm perturbs cell cycle progression, thus affecting AVE migration. These findings demonstrate that coordinated cell cycle progression during the implantation stages of development is important for post-implantation morphogenesis in the mouse embryo. |
