| Primary Identifier | MGI:8437133 | Allele Type | Endonuclease-mediated |
| Gene | Cdh5 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Glycine codons 649 (GGC) and 650 and 651(GGT) were changed top alanine (GCA) (p.G649_G651delinsAAA) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation abolishes binding of the encoded protein to the Ctnnd1 protein, which leads to microvascular hemorrhaging and decreased survival. |
