| Primary Identifier | MGI:8437137 | Allele Type | Endonuclease-mediated |
| Gene | Cdh5 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The sequence coding for the juxta-membrane domain (JMD) was targeted using an sgRNA with CRISPR/Cas9 technology, resulting in a 33 bp deletion (codons L642-E652). The in-frame deletion abolishes binding of the encoded protein to the Ctnnd1 protein, which leads to microvascular hemorrhaging and decreased survival. |
