| First Author | Nagai M | Year | 2019 |
| Journal | Cell | Volume | 178 |
| Issue | 5 | Pages | 1072-1087.e14 |
| PubMed ID | 31442401 | Mgi Jnum | J:339337 |
| Mgi Id | MGI:7520740 | Doi | 10.1016/j.cell.2019.07.047 |
| Citation | Nagai M, et al. (2019) Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses. Cell 178(5):1072-1087.e14 |
| abstractText | Nutritional status potentially influences immune responses; however, how nutritional signals regulate cellular dynamics and functionality remains obscure. Herein, we report that temporary fasting drastically reduces the number of lymphocytes by approximately 50% in Peyer's patches (PPs), the inductive site of the gut immune response. Subsequent refeeding seemingly restored the number of lymphocytes, but whose cellular composition was conspicuously altered. A large portion of germinal center and IgA(+) B cells were lost via apoptosis during fasting. Meanwhile, naive B cells migrated from PPs to the bone marrow during fasting and then back to PPs during refeeding when stromal cells sensed nutritional signals and upregulated CXCL13 expression to recruit naive B cells. Furthermore, temporal fasting before oral immunization with ovalbumin abolished the induction of antigen-specific IgA, failed to induce oral tolerance, and eventually exacerbated food antigen-induced diarrhea. Thus, nutritional signals are critical in maintaining gut immune homeostasis. |
