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Allele : Gt(ROSA)26Sor<em1(CAG-jRGECO1a,-ADRA2A*/GFP)Yuli> gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Yulong Li
Primary Identifier  MGI:8246652 Allele Type  Endonuclease-mediated
Attribute String  Conditional ready, Reporter Gene  Gt(ROSA)26Sor
Strain of Origin  C57BL/6NCrl Is Recombinase  false
Is Wild Type  false
molecularNote  Using CRISPR/cas9 methodologies (sgRNA: AAGGCCGCACCCTTCTCCGGAGG), the targeting construct composed of (from 5' to 3') CAG-loxP-STOP-loxP-jRGECO1a-iP2A-GRAB)NE2m(-WPRE-bGH pA was inserted into Gt(ROSA)26Sor locus. The STOP codon is composed of a pBS302 STOP cassette. jRGECO1a encodes a red fluorescent calcium sensor. GRAB)NE2m (encodes a second-generation GPCR-activation-based green fluorescent norepinephrine sensor (variant of Adra2a).
  • mutations:
  • Insertion
  • synonyms:
  • dual-NECa,
  • dual-NECa
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