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Allele : Gt(ROSA)26Sor<tm1.1(CAG-TVA,-EGFP,-RABVgp4*)Velm> gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Dmitry Velmeshev
Primary Identifier  MGI:8275289 Allele Type  Targeted
Attribute String  Reporter Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  (129S6/SvEvTac x C57BL/6NCrl)F1
Is Recombinase  false Is Wild Type  false
molecularNote  A CAG-loxP-Stop-loxP-TVA-P2A-EGFP-P2A-oG-attB-neomycin-attP cassette was inserted into the mouse Gt(ROSA)26Sor locus via homologous recombination. CAG is the CMV-IE enhancer/chicken beta-actin/rabbit beta-globin hybrid promoter. TVA represents an avian-specific retroviral receptor required for infection by EnvA-pseudotyped rabies virus. EGFP represents the enhanced green fluorescent reporter. oG is the optimized rabies glycoprotein that supports trans-synaptic spread. The neo cassette was removed with the phiC31 recombinase.
  • mutations:
  • Insertion
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Trail: Allele

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