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Allele : Gt(ROSA)26Sor<tm3(EWSR1/CREB3L1)Cklr> gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Charles Keller
Primary Identifier  MGI:8270521 Allele Type  Targeted
Attribute String  Conditional ready, Inserted expressed sequence Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  C57BL/6J
Is Recombinase  false Is Wild Type  false
molecularNote  The allele contains (from 5' to 3') a loxP site, a neomycin resistance (neo) cassette, a lox2272 site, a human Ewing sarcoma breakpoint region 1 fusion (EWSR1) cDNA fused to a human cAMP responsive element binding protein 3-like 1 (CREB3L1) cDNA with a polyadenylation signal, and second loxP and lox2272 sites in opposite orientations to their companion lox sites. The EWSR1::CREB3L1 fusion sequence is inserted in opposite orientation to the endogenous Gt(ROSA)26Sor gene.
  • mutations:
  • Insertion
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