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Allele : Gt(ROSA)26Sor<tm1(RIT1*)Abrg> gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Alice Berger
Primary Identifier  MGI:8378167 Allele Type  Targeted
Attribute String  Conditional ready, Humanized sequence, Inserted expressed sequence Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  129S1/Sv-Oca2<+> Tyr<+> Kitl<+>
Is Recombinase  false Is Wild Type  false
molecularNote  A floxed neomycin resistance (neo) cassette and STOP sequence, followed by a mutant human Ras-like without CAAX 1 (RIT1) cDNA sequence, an internal ribosome entry site (IRES), and an enhanced green fluorescent protein (EGFP) sequence were inserted into the Gt(ROSA)26Sor locus. The human RIT1 sequence contains an ATG to ATA nucleotide substitution that results in a methionine to isoleucine mutation at amino acid position 90 (M90I) associated with the promotion of lung tumorigenesis.
  • mutations:
  • Insertion
  • synonyms:
  • Rosa26-LSL-RIT1<M90I>,
  • Rosa26-LSL-RIT1<M90I>
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