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DO Term : BN2 diffuse large B-cell lymphoma [DOID:0081064] Disease Ontology

Namespace  disease_ontology Obsolete  false
description  A diffuse large B-cell lymphoma that is categorized as BN2 with high probability by the LymphGen algorithm. This is based on a combination of genetic features and BN2 DLBCLs often, but do not always, have a translocation involving the BCL6 locus and/or some combination of mutations affecting NOTCH2, TNFAIP3, BCL10 and UBE2A. This subgroup also commonly has mutations due to aberrant somatic hypermutation affecting CD70, which can be coding or non-coding.
  • synonyms:
  • NCI:C148395,
  • BN2 DLBCL
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