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MP Term : abnormal kidney collecting duct alpha-intercalated cell morphology [MP:0011755] Mammalian Phenotype

Namespace

MPheno.ontology

Obsolete

false

description

any structural anomaly of the tall, columnar epithelial cells found on the kidney collecting duct epithelium which secrete acid (via an apical H+-ATPase and H+/K+ exchanger) in the form of hydrogen ions and reabsorb bicarbonate (via band 3, a basolateral Cl-/HCO3- exchanger);damage to the alpha-intercalated cell's ability to secrete acid can result in distal renal tubular acidosis

synonyms:
abnormal collecting duct type A intercalated cells,
abnormal kidney collecting duct A-type intercalated cells,
abnormal collecting duct alpha-intercalated cells

Phenotype

Mammalian phenotypes (MP terms) --> Mouse genes and models

Ontology

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Ontology Term --> All descendants

Ontology Term --> Direct children

Ontology Term --> Direct parents

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