Namespace | MPheno.ontology | Obsolete | false |
description | any functional anomaly of the primary cilia found on the epithelial cells of the bile duct and extending from their apical membrane into the ductal lumen; cholangiocyte cilia respond to mechanical stimuli (i.e. luminal fluid flow) by alterations in intracellular Ca2+ and cAMP and are thought to act as osmosensors that play an important role in ductal bile formation by detecting changes in luminal tonicity and inducing bicarbonate secretion |