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GO Term : symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity [GO:0039548] Gene Ontology
Namespace  biological_process Obsolete  false
description  A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host IRF3 (interferon regulatory factor-3). IRF3 is a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF3, which allows IRF3 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes.
  • synonyms:
  • inhibition of IRF3-dependent antiviral response,
  • suppression by virus of host IRF3 activity,
  • inhibition of host IRF3 by virus,
  • suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity,
  • suppression by virus of host interferon regulatory factor 3
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