| First Author | Salas R | Year | 2002 |
| Journal | Eur J Biochem | Volume | 269 |
| Issue | 1 | Pages | 317-25 |
| PubMed ID | 11784326 | Mgi Jnum | J:73799 |
| Mgi Id | MGI:2156897 | Doi | 10.1046/j.0014-2956.2001.02655.x |
| Citation | Salas R, et al. (2002) Induction of chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI ) gene expression is mediated by ETS factor binding sites. Eur J Biochem 269(1):317-25 |
| abstractText | Chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI, or NR2F1) is an orphan nuclear receptor that plays a major role in the development of the nervous system. We show here that three ETS response elements in the COUP-TFI promoter mediate its transcription. A reporter gene containing these ETS binding sites is activated by Ets-1, while the same reporter with point mutations on all three ETS response elements is not. We also show that Ets-1 binds to these response elements and that other ETS factors also transactivate the COUP-TFI promoter. In addition, COUP-TFI is coexpressed with some ETS factors in the mouse embryo. These results indicate that members of the ETS family can activate COUP-TFI gene expression. |
