This entry represents HAUS augmin-like complex subunit 5 (HAUS5) from eukaryotes. The HAUS augmin-like complex shares similarity with Drosophila Augmin that regulates gamma-tubulin localization in mitotic spindles, but not at the centrosome. It contributes to mitotic spindle assembly, maintenance of chromosome integrity and completion of cytokinesis [, ].Plant and animal augmin complexes have similar functions in microtubule nucleation and organisation in mitotic microtubule arrays. The human augmin complex contains 8 subunits []. The Arabidopsis augmin complex contains both conserved and unique subunits compared with its animal counterparts []. This entry includes plant AUG5.
Assembly of a robust microtubule-based mitotic spindle is essential for accurate segregation of chromosomes to progeny. Spindle assembly relies on the concerted action of centrosomes, spindle microtubules, molecular motors and non-motor spindle proteins []. A number of novel regulators of spindle assembly have been identified: one of these is HAUS, an 8-subunit protein complex that shares similarity with Drosophila Augmin [, ]. The HAUS (Homologous to AUgmin Subunits) individual subunits have been designated HAUS1 to HAUS8. HAUS5 contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex [, ]. This entry represents HAUS5 from animals.
